IGF-I, IGF binding protein-3 and breast cancer risk: Comparison of 3 meta-analyses
نویسندگان
چکیده
منابع مشابه
Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on.
Insulin-like growth factor (IGF)-I, and its main binding protein, IGFBP-3, are multi-functional regulatory peptides of cell growth and survival, attributes important for tumourigenesis. Following seminal work published in 1998, it has been hypothesised that circulating concentrations of these growth factors may be associated with cancer risk. Systematic reviews have reported that high normal ra...
متن کاملNo association between serum insulin-like growth factor (IGF)-I, IGF-binding protein-3, and lung cancer risk.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland; Information Management Services, Inc., Silver Spring, Maryland; Departments of Medicine and Oncology, Lady Davis Research Institute of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada; and Department of Health Promotion and Chronic Disease Prevention, National Publi...
متن کاملCentral and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action.
IGF-I is recognized as an insulin sensitizer at the liver and muscle, while recent evidence suggests that IGF-binding protein (IGFBP)-3 acts as an insulin antagonist. As there is a paucity of IGF-I receptors in the liver and as the IGF-IGFBP system in the central nervous system is emerging as physiologically relevant, we examined whether the effects of IGF-I and IGFBP-3 on insulin action are me...
متن کاملRe: Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.
A recent study (1) suggested that elevated plasma levels of insulin-like growth factor-I (IGF-I) were a predictor of advanced-stage prostate cancer. We have studied IGF-I in prostate cancer and have found no relationship to disease stage. We studied IGF-I in a group of 126 men with prostate cancer and benign prostatic hypertrophy (BPH). Participants in our study were found through urology and r...
متن کاملInsulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.
BACKGROUND Plasma levels of insulin-like growth factor-I (IGF-I) have been associated with the risk of prostate cancer. However, the association of IGF-I with specific tumor stage and grade at diagnosis, which correlate with risk of recurrence and mortality, has not been studied rigorously. To determine whether plasma levels of IGF-I and its main circulating binding protein, IGF binding protein...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2005
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.20975